His parents, especially his mother, wanted to see Manolis Kalomiris become a doctor. But music ran in his veins. After he finished his high school studies in Constantinople, he went to Vienna to study music. From there, his next stop was Russia and then Athens.
As a teacher at the “Athens Conservatory,” he founded the “Greek Conservatory” and later the “National Conservatory,” thus enhancing the musical horizons of the country. He was a sworn enemy of the demotic language and, yet, he used the popular language of the ordinary people in the program of his first concert in Athens, after his return from Moscow.